TCS 401

TCS 401 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B) .

Product Specifications

CAS Number

[243966-09-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/TCS-401.html

Purity

98.0

Solubility

0.1 M NaOH : 6.67 mg/mL (ultrasonic; adjust pH to 9 with NaOH)

Smiles

O=C(C1=C(NC(C(O)=O)=O)SC2=C1CCNC2)O.[H]Cl

Molecular Formula

C10H11ClN2O5S

Molecular Weight

306.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31.|[2]Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304 (6) :F698-709.