Betahistine (dihydrochloride)

Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist[1]. Betahistine dihydrochloride is used for the study of rheumatoid arthritis (RA) [3].

Product Specifications

CAS Number

[5579-84-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Endocrinology; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Betahistine-dihydrochloride.html

Concentration

10mM

Purity

99.82

Solubility

DMF : 5 mg/mL (ultrasonic) |DMSO : 33.33 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

CNCCC1=CC=CC=N1.Cl.Cl

Molecular Formula

C8H14Cl2N2

Molecular Weight

209.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Poyurovsky M, et al. The effect of betahistine, a histamine H1 receptor agonist/H3 antagonist, on olanzapine-induced weight gain in first-episode schizophrenia patients. Int Clin Psychopharmacol. 2005 Mar;20 (2) :101-3.|[2]Gbahou F, et al. Effects of betahistine at histamine H3 receptors: mixed inverse agonism/agonism in vitro and partial inverse agonism in vivo.J Pharmacol Exp Ther. 2010 Sep 1;334 (3) :945-54.|[3]Tang KT, et al. Betahistine attenuates murine collagen-induced arthritis by suppressing both inflammatory and Th17 cell responses.Int Immunopharmacol. 2016 Oct;39:236-245.