Retrorsine N-oxide

Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides[1][2].

Product Specifications

CAS Number

[15503-86-3]

UNSPSC

12352005

Hazard Statement

H300-H373

Target

NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/retrorsine-n-oxide.html

Solubility

10 mM in DMSO

Smiles

O=C(/C(C[C@H]([C@@](O)(C(OCC1=CC2)=O)CO)C)=C\C)O[C@@]3([H])[C@]1([H])[N+]2([O-])CC3

Molecular Formula

C18H25NO7

Molecular Weight

367.39

Precautions

P260-P264-P270-P330-P405-P501

References & Citations

[1]He X, et, al. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25 (4) :984-991.|[2]Valese AC, et, al. Quantification of pyrrolizidine alkaloids in Senecio brasiliensis, beehive pollen, and honey by LC-MS/MS. J Environ Sci Health B. 2021;56 (7) :685-694.