6′-Amino-D-luciferin

6’-Amino-D-luciferin is a derivative of D-luciferin (HY-12591A) with an amino group replacing the 6-hydroxyl group. 6’-Amino-D-luciferin is a natural substrate of luciferase (Luc) and can be used for IVIS imaging in cell/animal experiments[1][2][3].

Product Specifications

CAS Number

[161055-47-6]

UNSPSC

12171500

Hazard Statement

H302-H312-H332

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/6-amino-d-luciferin.html

Purity

98.01

Solubility

DMSO : 12.5 mg/mL (ultrasonic)

Smiles

O=C([C@@H]1N=C(C2=NC3=CC=C(N)C=C3S2)SC1)O

Molecular Formula

C11H9N3O2S2

Molecular Weight

279.34

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Viviani VR, et al. Bioluminescence of beetle luciferases with 6'-amino-D-luciferin analogues reveals excited keto-oxyluciferin as the emitter and phenolate/luciferin binding site interactions modulate bioluminescence colors. Biochemistry. 2014 Aug 19;53 (32) :5208-20|[2]Conley NR, et al. A selenium analogue of firefly D-luciferin with red-shifted bioluminescence emission. Angew Chem Int Ed Engl. 2012 Apr 2;51 (14) :3350-3.|[3]Kovács AK, et al. Synthesis of N-peptide-6-amino-D-luciferin Conjugates. Front Chem. 2018 Apr 19;6:120.