Debrisoquin

Debrisoquin (Isocaramidine) is a TMPRSS2 inhibitors that inhibits SARS-CoV-2 entry into human lung cell line by a TMPRSS2-depedent manner, with an IC50 of 22μM. Debrisoquin can be used for antiviral research[1].

Product Specifications

CAS Number

[1131-64-2]

Product Name Alternative

Debrisoquine; Isocaramidine; Ro 5-3307/1

UNSPSC

12352005

Target

SARS-CoV; Ser/Thr Protease

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Debrisoquin.html

Solubility

10 mM in DMSO

Smiles

NC(N1CCC2=C(C1)C=CC=C2)=N

Molecular Formula

C10H13N3

Molecular Weight

175.23

References & Citations

[1]Amanda L. Peiffer, et.al.TMPRSS2 Inhibitor Discovery Facilitated through an In Silico and Biochemical Screening Platform.ACS Medicinal Chemistry Letters 2023 14 (6), 860-866.