Abanoquil

Abanoquil (U-K52046), an potent and selective α-1 adrenoceptor antagonist, is an anti-arrhythmic agent. Abanoquil can be used for erectile dysfunction research[1][2].

Product Specifications

CAS Number

[90402-40-7]

Product Name Alternative

U-K52046; Albanoquil

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/abanoquil.html

Concentration

10mM

Purity

98.07

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=CC(N2CC3=CC(OC)=C(OC)C=C3CC2)=NC4=CC(OC)=C(OC)C=C14

Molecular Formula

C22H25N3O4

Molecular Weight

395.45

References & Citations

[1]A Giraldi, et al. Abanoquil, a new alpha-1 adrenoceptor antagonist. In vitro and in vivo effect on erectile tissue. Int J Impot Res. 2000 Mar;12 (S1) :S37-S40.|[2]T C Tham, et al. Dose-dependent alpha 1-adrenoceptor antagonist activity of the anti-arrhythmic drug, abanoquil (UK-52,046), without reduction in blood pressure in man. Br J Clin Pharmacol. 1992 Apr;33 (4) :405-9.