Imeglimin (hydrochloride)

Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].

Product Specifications

CAS Number

[775351-61-6]

Product Name Alternative

EMD 387008 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/imeglimin-hydrochloride.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

[H]Cl.NC1=N[C@@H](C)N=C(N(C)C)N1

Molecular Formula

C6H14ClN5

Molecular Weight

191.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64 (6) :2254-64.|[2]Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.