Nortriptyline (hydrochloride)

Nortriptyline (Desmethylamitriptyline) hydrochloride, the main active metabolite of Amitriptyline, is a tricyclic antidepressant. Nortriptyline hydrochloride is a potent autophagy inhibitor and has anticancer effects[1][2][3].

Product Specifications

CAS Number

[894-71-3]

Product Name Alternative

Desmethylamitriptyline (hydrochloride) ; Desitriptilina (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Drug Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Nortriptyline-hydrochloride.html

Purity

99.98

Solubility

DMSO : 70 mg/mL (ultrasonic) |H2O : 7.14 mg/mL (ultrasonic)

Smiles

CNCC/C=C1C2=CC=CC=C2CCC3=CC=CC=C\13.[H]Cl

Molecular Formula

C19H22ClN

Molecular Weight

299.85

Precautions

H302

References & Citations

[1]Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US) ; 2012-2017 Mar 23.|[2]Petrosyan E, et al. Repurposing Autophagy Regulators in Brain Tumors [published online ahead of print, 2022 Feb 18]. Int J Cancer. 2022;10.1002/ijc.33965. |[3]Sheau-Yun Yuan, et al. Nortriptyline induces mitochondria and death receptor-mediated apoptosis in bladder cancer cells and inhibits bladder tumor growth in vivo. Eur J Pharmacol. 2015 Aug 15:761:309-20.