AZ960
AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.
Product Specifications
CAS Number
[905586-69-8]
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; JAK; Parasite; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ960.html
Concentration
10mM
Purity
97.08
Solubility
DMSO : ≥ 30 mg/mL
Smiles
N#CC1=CC(F)=C(NC2=NNC(C)=C2)N=C1N[C@H](C3=CC=C(F)C=C3)C
Molecular Formula
C18H16F2N6
Molecular Weight
354.36
Precautions
H302
References & Citations
[1]Ikezoe T, et al. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. Int J Cancer. 2011 Nov 15;129 (10) :2512-21.|[2]Yang J, et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010 Dec;9 (12) :3386-95.|[3]Valenciano AL, et al. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Bioorg Med Chem. 2016 Oct 1;24 (19) :4647-51.|[4]Gozgit JM, et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283 (47) :32334-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2; JAK3
Available Sizes
Curated Selection
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