AZ960

AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.

Product Specifications

CAS Number

[905586-69-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; JAK; Parasite; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZ960.html

Concentration

10mM

Purity

97.08

Solubility

DMSO : ≥ 30 mg/mL

Smiles

N#CC1=CC(F)=C(NC2=NNC(C)=C2)N=C1N[C@H](C3=CC=C(F)C=C3)C

Molecular Formula

C18H16F2N6

Molecular Weight

354.36

Precautions

H302

References & Citations

[1]Ikezoe T, et al. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. Int J Cancer. 2011 Nov 15;129 (10) :2512-21.|[2]Yang J, et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010 Dec;9 (12) :3386-95.|[3]Valenciano AL, et al. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Bioorg Med Chem. 2016 Oct 1;24 (19) :4647-51.|[4]Gozgit JM, et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283 (47) :32334-43.