What is the catalog number for AZ960?

The catalog number for AZ960 is HY-10411.

What sizes are available for AZ960?

AZ960 is available in the following size(s): 1 mg, 10 mM - 1 mL, 5 mg, 10 mg, 50 mg, 100 mg.

How many pack sizes does AZ960 come in?

AZ960 is available in 6 different pack sizes.

AZ960 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AZ960?

AZ960 is manufactured by QuantiMol.

What is the estimated delivery time for AZ960?

Estimated delivery time for AZ960 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for AZ960?

The safety data sheet for AZ960 is available here: http://file.medchemexpress.com/batch_PDF/HY-10411/AZ960-SDS-MedChemExpress.pdf.

AZ960

AZ960 is a potent and specific inhibitor of the JAK2 kinase with a Ki of 0.45 nM.

Product Specifications

CAS Number

905586-69-8

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; JAK; Parasite; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZ960.html

Concentration

10mM

Purity

97.08

Solubility

DMSO : ≥ 30 mg/mL

Smiles

N#CC1=CC(F)=C(NC2=NNC(C)=C2)N=C1N[C@H](C3=CC=C(F)C=C3)C

Molecular Formula

C18H16F2N6

Molecular Weight

354.36

Precautions

H302

References & Citations

[1]Ikezoe T, et al. Expression of p-JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia. Int J Cancer. 2011 Nov 15;129 (10) :2512-21.|[2]Yang J, et al. AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells. Mol Cancer Ther. 2010 Dec;9 (12) :3386-95.|[3]Valenciano AL, et al. Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor. Bioorg Med Chem. 2016 Oct 1;24 (19) :4647-51.|[4]Gozgit JM, et al. Effects of the JAK2 inhibitor, AZ960, on Pim/BAD/BCL-xL survival signaling in the human JAK2 V617F cell line SET-2. J Biol Chem. 2008 Nov 21;283 (47) :32334-43.