Doxofylline-d4

Doxofylline-d4 is the deuterium labeled Doxofylline. Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV[1][2].

Product Specifications

CAS Number

[1346599-13-0]

UNSPSC

12352005

Target

Adenosine Receptor; Isotope-Labeled Compounds; Phosphodiesterase (PDE)

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

C(N1C2=C(N(C)C(=O)N(C)C2=O)N=C1)C3OC(C(O3)([2H])[2H])([2H])[2H]

Molecular Formula

C11H10D4N4O4

Molecular Weight

270.28

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10 (14) :2343-56.