Org OD 02-0
Product Specifications
Product Name Alternative
10-Ethenyl-19-norprogesterone
UNSPSC Description
Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2].
Target Antigen
p38 MAPK; Progesterone Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway;Vitamin D Related/Nuclear Receptor
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/org-od-02-0.html
Purity
99.7
Solubility
DMSO : 24 mg/mL (ultrasonic;warming)
Smiles
CC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C=C)[C@@]3([H])CC[C@]12C)=O)=O
Molecular Weight
326.47
References & Citations
[1]Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75(4-5):314-22.|[2]Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30(9):e12614.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131547/Org-OD-02-0-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131547/Org-OD-02-0-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
13258-85-0
Available Sizes
Curated Selection
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