Org OD 02-0

Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα) -specific agonist (IC50: 33.9 nM) . Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary[1][2].

Product Specifications

CAS Number

[13258-85-0]

Product Name Alternative

10-Ethenyl-19-norprogesterone

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

P38 MAPK; Progesterone Receptor

Type

Reference compound

Related Pathways

MAPK/ERK Pathway; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/org-od-02-0.html

Purity

99.7

Solubility

DMSO : 24 mg/mL (ultrasonic; warming)

Smiles

CC([C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C=C)[C@@]3([H])CC[C@]12C)=O)=O

Molecular Formula

C22H30O2

Molecular Weight

326.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Kelder J, et al. Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids. 2010 Apr;75 (4-5) :314-22.|[2]Camilletti MA, et al. Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion. J Neuroendocrinol. 2018 Sep;30 (9) :e12614.