Recombinant Human M-CSF

M-CSF, also known as CSF-1, is a four alpha -helical-bundle cytokine, mainly produced by mononuclear macrophages, lymphocytes, endothelial cells, fibroblasts, epithelial cells, etc. M-CSF is the main regulator of macrophage survival, proliferation, and differentiation. M-CSF can promote and enhance the killing of macrophages on tumor cells and microorganisms, regulate the release of cytokines and other inflammatory regulators by macrophages, and stimulate cytophagocytosis. M-CSF also plays an important role in regulating osteoclast proliferation and differentiation, and regulating bone resorption, and is necessary for normal bone development. Recombinant Human M-CSF is produced by E.coli expression system, and is produced with raw materials of pharmaceutical applicable level. The host protein residue, nucleic acid residue and common pathogens are strictly controlled, and the production and quality management procedures of the product comply with GMP regulations to ensure the traceability of the production process and all raw materials.