Sacubitril-13C4 (hemicalcium salt)
Product Specifications
UNSPSC Description
Sacubitril-13C4 (hemicalcium salt) is a 13C-labeled and deuterium labeled Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril hemicalcium salt is a component of the heart failure medicine LCZ696[1].
Target Antigen
Isotope-Labeled Compounds; Neprilysin
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sacubitril-13c4-hemicalcium-salt.html
Solubility
10 mM in DMSO
Smiles
O=[13C]([13CH2][13CH2][13C]([O-])=O)N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@@H](C)C(OCC)=O.[0.5Ca2+]
Molecular Weight
434.49
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Ksander GM, et al. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12;38(10):1689-700.;Voors AA, et al. The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.;von Lueder TG, et al. Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. Circ Heart Fail. 2015 Jan;8(1):71-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-15407AS/Sacubitril-13C4-hemicalcium-salt-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-15407AS/
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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