BMP-4
BMP-4 is a penetrating heparin-binding peptide with anti-inflammatory and anti-chondrogenic functions. In murine chondrocytes and macrophages, BMP-4 regulates the iNOS-IFN-IL6 signaling pathway to inhibit the expression of inflammatory proteins such as iNOS, COX2, IFN, and IL6 in a dose-dependent manner, effectively suppressing inflammation and alleviating various arthritis symptoms[1].
Product Specifications
CAS Number
1629625-47-3
UNSPSC
12352209
Target
COX; IFNAR; Interleukin Related
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bmp-4.html
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N1[C@@H](CCC1)C(N[C@@H](CC(N)=O)C(N[C@@H](CS)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2=CNC=N2)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCNC(N)=N)N
Molecular Formula
C52H93N25O13S
Molecular Weight
1308.52
References & Citations
[1]Pathade V, et al. Emerging insights of peptide-based nanotherapeutics for effective management of rheumatoid arthritis. Life Sci. 2023 Jan 1;312:121257.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
COX-2; IL-6
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