EGFR-IN-86
EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase[1].
Product Specifications
CAS Number
3055550-22-3
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-86.html
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=C1)=NN1C2=NC(NC3=C(S(=O)(N4CCC4)=O)C=CC=C3)=C5C(N(C)C=C5)=N2
Molecular Formula
C20H21N7O2S
Molecular Weight
423.49
References & Citations
[1]Zhang Y, et al. Design and discovery of novel pyrazole-pyrrolopyrimidine derivatives as anti-glioma agents via promoting apoptosis, inhibiting cell cycle and EGFR-TK. Chem Biol Drug Des. 2023 Aug 28.. .
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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