EGFR-IN-86

EGFR-IN-86 (compound 4i) is an EGFR inhibitor (IC50: 1.5 nM) with high activity against glioblastoma. EGFR-IN-86 induces apoptosis and arrests the U87 cell cycle in the G2/M phase[1].

Product Specifications

CAS Number

[3055550-22-3]

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-86.html

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C=C1)=NN1C2=NC(NC3=C(S(=O)(N4CCC4)=O)C=CC=C3)=C5C(N(C)C=C5)=N2

Molecular Formula

C20H21N7O2S

Molecular Weight

423.49

References & Citations

[1]Zhang Y, et al. Design and discovery of novel pyrazole-pyrrolopyrimidine derivatives as anti-glioma agents via promoting apoptosis, inhibiting cell cycle and EGFR-TK. Chem Biol Drug Des. 2023 Aug 28.. .