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GRN-529

GRN-529 is a negative allosteric modulator (NAM) for mGluR5. GRN-259 modulates sleep-wake activity, and exhibits anxiolytic efficacy in rats[1].

Product Specifications

CAS Number

1253291-12-1

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/grn-529.html

Smiles

O=C(N1CC2=NC=CC=C2C1)C3=CC=C(C(C#CC4=NC=CC=C4)=C3)OC(F)F

Molecular Formula

C22H15F2N3O2

Molecular Weight

391.37

References & Citations

[1]Harvey BD, et al., Neurophysiological signals as potential translatable biomarkers for modulation of metabotropic glutamate 5 receptors. Neuropharmacology. 2013 Dec;75:19-30.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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