10-Hydroxydecanoic acid

10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells[1][2][3][4][5].

Product Specifications

CAS Number

[1679-53-4]

Product Name Alternative

NSC 15139; 10-HDAA

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Caspase; Interleukin Related; MDM-2/p53; NF-κB; NO Synthase; Parasite; RANKL/RANK ; TNF Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/NSC_15139.html

Purity

99.77

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(O)CCCCCCCCCO

Molecular Formula

C10H20O3

Molecular Weight

188.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Takahashi K, et al. Inhibitory effect of 10-hydroxydecanoic acid on lipopolysaccharide-induced nitric oxide production via translational downregulation of interferon regulatory factor-1 in RAW264 murine macrophages. Biomed Res. 2013 Aug;34 (4) :205-14.|[2]Isayama, et al. "10-Hydroxydecanoic acid potentially elicits antigen-specific IgA responses." Biological and Pharmaceutical Bulletin 43.8 (2020) : 1202-1209.|[3]Alkhaibari, et al. Insecticidal, antimalarial, and antileishmanial effects of royal jelly and its three main fatty acids, trans‐10‐hydroxy‐2‐decenoic acid, 10‐hydroxydecanoic acid, and sebacic acid. Evidence‐Based Complementary and Alternative Medicine 2022.1 (2022) : 7425322.|[4]Mengmeng, et al. "10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells." International Immunopharmacology 84 (2020) : 106501.|[5]Mengmeng, et al. "Combined royal jelly 10-hydroxydecanoic acid and aspirin has a synergistic effect against memory deficit and neuroinflammation." Food & Function 13.4 (2022) : 2336-2353.