3-Methylxanthine

3-Methylxanthine, a xanthine derivative, is a cyclic guanosine monophosphate (GMP) inhibitor, with an IC50 of 920 μM on guinea-pig isolated trachealis muscle.

Product Specifications

CAS Number

[1076-22-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/3-Methylxanthine.html

Purity

99.78

Solubility

1M NaOH : 50 mg/mL (ultrasonic; adjust pH to 11 with 1M NaOH) |DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL

Smiles

O=C1N(C)C2=C(N=CN2)C(N1)=O

Molecular Formula

C6H6N4O2

Molecular Weight

166.14

Precautions

H302

References & Citations

[1]Tanaka H, et al. Inhibition of cyclic GMP phosphodiesterase by xanthine derivatives relaxes guinea-pig trachealis smooth muscle. Clin Exp Pharmacol Physiol. 1991 Mar;18 (3) :163-8.|[2]Yamamoto K, et al. Neurotoxic convulsions induced by theophylline and its metabolites in mice. Biol Pharm Bull. 1996 Jun;19 (6) :869-72.