Caerulomycin A
Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases[1].
Product Specifications
CAS Number
21802-37-9
Product Name Alternative
Cerulomycin; Caerulomycin
UNSPSC
12352005
Hazard Statement
H301, H315, H319
Target
Antibiotic; Fungal
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Caerulomycin_A.html
Purity
98.0
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
COC1=CC(C2=NC=CC=C2)=NC(/C=N/O)=C1
Molecular Formula
C12H11N3O2
Molecular Weight
229.24
Precautions
H301, H315, H319
References & Citations
[1]Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β) -Smad3 protein signaling by suppressing interferon-γ (IFN-γ) -signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs) . J Biol Chem. 2014 Jun 20;289 (25) :17515-28.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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