Caerulomycin A

Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases[1].

Product Specifications

CAS Number

[21802-37-9]

Product Name Alternative

Cerulomycin; Caerulomycin

UNSPSC

12352005

Hazard Statement

H301, H315, H319

Target

Antibiotic; Fungal

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Caerulomycin_A.html

Purity

98.0

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

COC1=CC(C2=NC=CC=C2)=NC(/C=N/O)=C1

Molecular Formula

C12H11N3O2

Molecular Weight

229.24

Precautions

H301, H315, H319

References & Citations

[1]Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β) -Smad3 protein signaling by suppressing interferon-γ (IFN-γ) -signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs) . J Biol Chem. 2014 Jun 20;289 (25) :17515-28.