FIIN-3
FIIN-3 is an irreversible inhibitor of FGFR with an IC50 of 13.1, 21, 31.4, and 35.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively.
Product Specifications
CAS Number
[1637735-84-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; FGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FIIN-3.html
Purity
99.66
Solubility
DMSO : 10 mg/mL (ultrasonic; warming)
Smiles
C=CC(NC1=CC=C(CN(C(NC2=C(Cl)C(OC)=CC(OC)=C2Cl)=O)C3=NC=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=C3)C=C1)=O
Molecular Formula
C34H36Cl2N8O4
Molecular Weight
691.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Tan L et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A, 2014 Nov 11, 111 (45) :E4869-77
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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