1-Palmitoyl-sn-glycero-3-phosphocholine-d9-1

1-Palmitoyl-sn-glycero-3-phosphocholine-d9-1 (16:0 Lyso PC-d9-1) is deuterium labeled 1-Palmitoyl-sn-glycero-3-phosphocholine (HY-125783) . 1-Palmitoyl-sn-glycero-3-phosphocholine (16:0 Lyso PC) is an abundant lysophosphatidylcholine. 1-Palmitoyl-sn-glycero-3-phosphocholine exhibits proinflammatory activity. 1-Palmitoyl-sn-glycero-3-phosphocholine can be used in the study of atherosclerosis[1][2][3][4].

Product Specifications

CAS Number

[182257-09-6]

Product Name Alternative

16:0 Lyso PC-d9-1

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=P(OC[C@@](O)([H])COC(CCCCCCCCCCCCCCC)=O)([O-])OCC[N+](C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H]

Molecular Formula

C24H41D9NO7P

Molecular Weight

504.69

Precautions

H302, H315, H319, H335

References & Citations

[1]Choi S, et al. Superoxide generated by lysophosphatidylcholine induces endothelial nitric oxide synthase downregulation in human endothelial cells. Cell Physiol Biochem. 2010;25 (2-3) :233-40. |[2]Qin X, et al. Lysophosphatidylcholine perpetuates macrophage polarization toward classically activated phenotype in inflammation. Cell Immunol. 2014 May-Jun;289 (1-2) :185-90. |[3]Hasegawa H, et al. Lysophosphatidylcholine enhances the suppressive function of human naturally occurring regulatory T cells through TGF-β production. Biochem Biophys Res Commun. 2011 Nov 25;415 (3) :526-31. |[4]Yan JJ, et al. Therapeutic effects of lysophosphatidylcholine in experimental sepsis. Nat Med. 2004 Feb;10 (2) :161-7.