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Recombinant Human BCMA (C-Fc)

Recombinant Human B-cell Maturation Protein is produced by our Mammalian expression system and the target gene encoding Met1-Ala54 is expressed with a Fc tag at the C-terminus.

Product Specifications

Background

B cell maturation protein (BCMA) is a type III membrane protein which belongs to the TNF receptor superfamily (TNFRSF17) . BCMA contains one extracellular cysteine rich domain, as well as TACI. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity. BCMA is mainly expressed in immune organs and mature B cell lines. BCMA appears to be localized to the Golgi compartment. BCMA may play an important role in B cell development, function and regulation.

UniProt

Q02223

Accession Number

Q02223

Endotoxin

Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Bioactivity

Loaded Mouse BAFF-mFc (Cat#C06U) on AMC Biosensor, can bind Human BCMA-Fc (Cat#CS79) with an affinity constant of 0.44 nM as determined in BLI assay.

Molecular Weight

32.8 KDa

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Storage Conditions

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Storage Temperature

Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Notes

Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Observed Molecular Weight

38-40 KDa, reducing conditions

Other Product Names

Tumor necrosis factor receptor superfamily member 17; TNFRSF17; B-cell maturation protein; CD269

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