BRD73954
BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 μM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin[1].
Product Specifications
CAS Number
1440209-96-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BRD73954.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC(C(NCCC2=CC=CC=C2)=O)=C1)NO
Molecular Formula
C16H16N2O3
Molecular Weight
284.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Olson DE, et, al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56 (11) :4816-20.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6; HDAC8
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
J Young Norell Select Series NMR Tube With 5mm NMR Valve 800mhz 7 Long
