Isorhamnetin

Isorhamnetin is a flavonoid compound extracted from the Chinese herb Hippophae rhamnoides L.. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3K.

Product Specifications

CAS Number

[480-19-3]

Product Name Alternative

3'-Methylquercetin

UNSPSC

12352005

Hazard Statement

H351

Target

Endogenous Metabolite; MEK; PI3K

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Isorhamnetin.html

Purity

99.94

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13

Molecular Formula

C16H12O7

Molecular Weight

316.26

Precautions

H351

References & Citations

[1]Kim JE, et al. Isorhamnetin suppresses skin cancer through direct inhibition of MEK1 and PI3-K. Cancer Prev Res (Phila) . 2011 Apr;4 (4) :582-91.|[2]Hu S, et al. Isorhamnetin inhibits cell proliferation and induces apoptosis in breast cancer via Akt and mitogen activated protein kinase kinase signaling pathways. Mol Med Rep. 2015 Nov;12 (5) :6745-51.