5Me3F4AP

5Me3F4AP is a potent blocker of potassium channel, with the IC50 of 220 μM to 693 μM when the pH is increased from 6.4 to 9.1. 5Me3F4AP has the potential to cross the blood-brain barrier and potential application in positron emission tomography (PET) [1].

Product Specifications

CAS Number

[13958-85-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5me3f4ap.html

Purity

99.55

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC1=C(F)C=NC=C1C

Molecular Formula

C6H7FN2

Molecular Weight

126.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Sun Y, et al. Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine. Sci Rep. 2024 May 15;14 (1) :11105.