AZD5153 (6-Hydroxy-2-naphthoic acid)
Product Specifications
UNSPSC Description
AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM.
Target Antigen
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZD5153_6-Hydroxy-2-naphthoic_acid.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C2C=C(O)C=CC2=C1)O.O=C3N(C)CCN(CCOC4=CC=C(C5CCN(C6=NN7C(C=C6)=NN=C7OC)CC5)C=C4)[C@@H]3C
Molecular Weight
667.75
References & Citations
[1]Rhyasen GW, et al. AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.Front Cell Dev Biol. 2022 Mar 24:10:853652.|J Med Chem. 2020 Jul 9;63(13):7186-7210.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100653A/AZD5153-6-Hydroxy-2-naphthoic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100653A/AZD5153-6-Hydroxy-2-naphthoic-acid-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1869912-40-2
Available Sizes
Curated Selection
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