AZD5153 (6-Hydroxy-2-naphthoic acid)

AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM.

Product Specifications

CAS Number

[1869912-40-2]

UNSPSC

12352005

Hazard Statement

H302, H319, H332, H372, H400

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AZD5153_6-Hydroxy-2-naphthoic_acid.html

Concentration

10mM

Purity

99.51

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C2C=C(O)C=CC2=C1)O.O=C3N(C)CCN(CCOC4=CC=C(C5CCN(C6=NN7C(C=C6)=NN=C7OC)CC5)C=C4)[C@@H]3C

Molecular Formula

C36H41N7O6

Molecular Weight

667.75

Precautions

H302, H319, H332, H372, H400

References & Citations

[1]Rhyasen GW, et al. AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther. 2016 Nov;15 (11) :2563-2574.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Citation 01

Front Cell Dev Biol. 2022 Mar 24:10:853652.|bioRxiv. 2025 Sep 3:2025.08.30.673282.|J Biomed Mater Res A. 2025 Apr;113 (4) :e37909.|J Med Chem. 2020 Jul 9;63 (13) :7186-7210.|Mol Cancer Ther. 2025 Jul 2.