Losartan-d4 (carboxylic acid)
Losartan-d4 carboxylic acid (E-3174-d4) is the deuterium labeled Losartan Carboxylic Acid (HY-12765) . Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC) . Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
Product Specifications
CAS Number
[1246820-62-1]
Product Name Alternative
E-3174 D4; EXP-3174 D4
UNSPSC
12352005
Hazard Statement
H317, H360, H362
Target
Angiotensin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology; Cancer
Purity
98.09
Solubility
10 mM in DMSO|DMSO : ≥ 250mg/mL
Smiles
ClC1=C(C(O)=O)N(CC2=C([2H])C([2H])=C(C3=CC=CC=C3C4=NN=NN4)C([2H])=C2[2H])C(CCCC)=N1
Molecular Formula
C22H17D4ClN6O2
Molecular Weight
440.92
Precautions
H317, H360, H362
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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