Ro 363 (hydrochloride)
Ro 363 hydrochloride, an effective inotropic stimulant, is a potent and highly selective β1-adrenoceptor agonist. Ro 363 hydrochloride is a cardiovascular modulator that reduces diastolic blood pressure and pronounces increases in myocardial contractility[1][2][3].
Product Specifications
CAS Number
250580-70-2
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ro-363-hydrochloride.html
Purity
95.16
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)
Smiles
OC1=CC=C(OCC(O)CNCCC2=CC=C(OC)C(OC)=C2)C=C1O.[H]Cl
Molecular Formula
C19H26ClNO6
Molecular Weight
399.87
References & Citations
[1]Maccarrone C, et al. Comparison of the Arrhythmogenic Actions of (-) -Isoprenaline, Dobutamine and the selective beta 1-adrenoceptor agonist, (+/-) - (1-[3',4'-dihydroxyphenoxy] -2-hydroxy-[3",4"-dimethoxy phenethylamino]-propane) -oxalate (Ro 363) . Arzneimittelforschung. 1985;35 (3) :592-8.|[2]Iakovidis D, et al. In vitro activity of RO363, a beta1-adrenoceptor selective agonist. Br J Pharmacol. 1980 Apr;68 (4) :677-85.|[3]Einstein R, et al. Comparison of the cardiac effects of beta-adrenoreceptor agonists in anaesthetised and conscious dogs. J Auton Pharmacol. 1986 Mar;6 (1) :9-14.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor
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