Cobomarsen (sodium)
Product Specifications
Product Name Alternative
MRG-106 (sodium)
UNSPSC Description
Cobomarsen sodium is an oligonucleotide inhibitor of miR-155. Cobomarsen sodium inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen sodium can be used for the research of B-cell lymphoma[1][2].
Target Antigen
MicroRNA
Type
Oligonucleotides
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cobomarsen-sodium.html
Purity
92.58
Solubility
10 mM in H2O
Smiles
[Cobomarsen (sodium)]
Molecular Weight
5021.60
References & Citations
[1]Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183(3):428-444.|[2]Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27(4):1139-1149.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132601A/Cobomarsen-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132601A/Cobomarsen-sodium-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1848257-85-1
Available Sizes
Curated Selection
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