Cobomarsen (sodium)

Cobomarsen sodium is an oligonucleotide inhibitor of miR-155. Cobomarsen sodium inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT) . Cobomarsen sodium can be used for the research of B-cell lymphoma[1][2].

Product Specifications

CAS Number

[1848257-85-1]

Product Name Alternative

MRG-106 (sodium)

UNSPSC

12352208

Target

MicroRNA

Type

Oligonucleotides

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cobomarsen-sodium.html

Purity

99.29

Solubility

10 mM in H2O

Smiles

[Cobomarsen(sodium)]

Molecular Formula

C148H164N52Na13O77P13S13

Molecular Weight

4736 (free acid)

References & Citations

[1]Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183 (3) :428-444.|[2]Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27 (4) :1139-1149.