Cobomarsen (sodium)
Cobomarsen sodium is an oligonucleotide inhibitor of miR-155. Cobomarsen sodium inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT) . Cobomarsen sodium can be used for the research of B-cell lymphoma[1][2].
Product Specifications
CAS Number
[1848257-85-1]
Product Name Alternative
MRG-106 (sodium)
UNSPSC
12352208
Target
MicroRNA
Type
Oligonucleotides
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cobomarsen-sodium.html
Purity
99.29
Solubility
10 mM in H2O
Smiles
[Cobomarsen(sodium)]
Molecular Formula
C148H164N52Na13O77P13S13
Molecular Weight
4736 (free acid)
References & Citations
[1]Seto AG, et, al. Cobomarsen, an oligonucleotide inhibitor of miR-155, co-ordinately regulates multiple survival pathways to reduce cellular proliferation and survival in cutaneous T-cell lymphoma. Br J Haematol. 2018 Nov;183 (3) :428-444.|[2]Anastasiadou E, et, al. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell Growth In Vitro and In Vivo. Clin Cancer Res. 2021 Feb 15;27 (4) :1139-1149.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Available Sizes
Curated Selection
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