Nor-NOHA (dihydrochloride)

Nor-NOHA dihydrochloride is a selective and reversible arginase inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism[1].

Product Specifications

CAS Number

[291758-32-2]

Product Name Alternative

Nω-Hydroxy-nor-L-arginine (dihydrochloride)

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Arginase

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nor-noha-dihydrochloride.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC([C@@H](N)CCNC(NO)=N)=O.Cl.Cl

Molecular Formula

C5H14Cl2N4O3

Molecular Weight

249.10

Precautions

P261-P280-P302+P352

References & Citations

[1]Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13 (10) :e0205254.