(3S,4R) -GNE-6893
(3S,4R) -GNE-6893 is a potent and orally active HPK1 inhibitor. (3S,4R) -GNE-6893 can be used in research of cancer[1].
Product Specifications
CAS Number
[2415374-97-7]
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3s-4r-gne-6893.html
Purity
99.49
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=C(N)C(C=NC(NC(O[C@H]2[C@@H](COC2)C)=O)=C3)=C3C=C1C4=CN=C(OCCN5)C5=C4C
Molecular Formula
C23H24FN5O4
Molecular Weight
453.47
References & Citations
[1]Andreas S, et, al. A Convergent Synthesis of HPK1 Inhibitor GNE-6893 via Palladium-Catalyzed Functionalization of a Tetrasubstituted Isoquinoline. Org. Process Res. Dev. 2023;27 (3) :523-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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