HBX 28258
HBX 28258 is a selective USP7 inhibitor, with an IC50 of 22.6 μM. HBX 28258 can covalently binds to Cys223 located in the catalytic core of USP7, inhibits its deubiquitinating activity, promotes MDM2 protein degradation, and activates p53[1].
Product Specifications
CAS Number
1426544-54-8
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hbx-28258.html
Smiles
O=C(C1=CC2=C(N=C3C(CCCC3)=C2Cl)C=C1)NCCCN(CC)CC4=CC=CC=C4
Molecular Formula
C26H30ClN3O
Molecular Weight
435.99
References & Citations
[1]Qi SM, et, al. Targeting USP7-Mediated Deubiquitination of MDM2/MDMX-p53 Pathway for Cancer Therapy: Are We There Yet? Front Cell Dev Biol. 2020 Apr 2:8:233.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7
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