L-Thyroxine sodium xhydrate

L-Thyroxine sodium xhydrate (Levothyroxine; T4) is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active hormone (Triiodothyronine, T3) from L-Thyroxine (T4) .

Product Specifications

CAS Number

[25416-65-3]

Product Name Alternative

Sodium levothyroxine

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Thyroid Hormone Receptor

Type

Biochemical Assay Reagents

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/L-Thyroxine_sodium_xhydrate.html

Purity

99.30

Solubility

0.01 M NaOH : 2 mg/mL (ultrasonic; warming; adjust pH to 12 with NaOH; heat to 60°C) |DMSO : 50 mg/mL (ultrasonic)

Smiles

IC1=C(O)C(I)=CC(OC2=C(I)C=C(C[C@@](N)([H])C(O[Na])=O)C=C2I)=C1.O

Molecular Formula

C15H12I4NNaO5

Molecular Weight

816.87

Precautions

H302, H315, H319, H335

References & Citations

[1]Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Jan 11.|[2]Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2 (4) :144-149.