DLin-KC2-DMA

DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs) . DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP) . DLin-KC2-DMA can be used in siRNA delivery studies[1][2].

Product Specifications

CAS Number

[1190197-97-7]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Liposome

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/DLin-KC2-DMA.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

CCCCC/C=C\C/C=C\CCCCCCCCC1(CCCCCCCC/C=C\C/C=C\CCCCC)OC(CCN(C)C)CO1

Molecular Formula

C43H79NO2

Molecular Weight

642.09

Precautions

H315, H319

References & Citations

[1]Miller AD, et al. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10 (6) :781-811.|[2]Basha G, et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther. 2011 Dec;19 (12) :2186-200.