LCS-1

LCS-1 is a superoxide dismutase 1 (SOD1) inhibitor. LCS-1 inhibits SOD1 activity with an IC50 value of 1.07 μM. LCS-1 induces the early- and late-stage apoptosis of multiple myeloma (MM.1S) cells[1][2][3].

Product Specifications

CAS Number

[41931-13-9]

Product Name Alternative

MK-0364 (racemate),R816

UNSPSC

12352005

Hazard Statement

H301, H319

Target

Apoptosis; SOD

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lcs-1.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2

Molecular Formula

C11H8Cl2N2O

Molecular Weight

255.10

Precautions

H301, H319

References & Citations

[1]Gupta A, et al. Nanocarrier Composed of Magnetite Core Coated with Three Polymeric Shells Mediates LCS-1 Delivery for Synthetic Lethal Therapy of BLM-Defective Colorectal Cancer Cells. Biomacromolecules. 2018 Mar 12;19 (3) :803-815.|[2]Somwar R, et al. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proc Natl Acad Sci U S A. 2011;108 (39) :16375-16380.|[3]Du T, et al. Proteomic analysis identifies mechanism (s) of overcoming bortezomib resistance via targeting ubiquitin receptor Rpn13. Leukemia. 2021 Feb;35 (2) :550-561.