Pentixafor
Pentixafor is a peptide that targets CXCR4. Pentixafor is capable of being labelled with 68Gallium (68Ga) for positron emission tomography (PET) imaging[1][2][3][4]. Pentixafor can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs) .
Product Specifications
CAS Number
1341207-62-2
UNSPSC
12352209
Target
CXCR; Radionuclide-Drug Conjugates (RDCs)
Type
Peptides
Related Pathways
Antibody-drug Conjugate/ADC Related; GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pentixafor.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic) |Methanol : ≥ 125 mg/mL
Smiles
O=C(NCC(N[C@@H](C1=O)CC(C=C2)=CC=C2O)=O)[C@@H](NC([C@@H](NC([C@H](N1C)CCCNC(C(C=C3)=CC=C3CNC(CN(CCN(CC4)CC(O)=O)CCN(CCN4CC(O)=O)CC(O)=O)=O)=O)=O)CCCNC(N)=N)=O)CC5=CC(C=CC=C6)=C6C=C5
Molecular Formula
C60H80N14O14
Molecular Weight
1221.36
References & Citations
[1]Buck AK, et al. CXCR4-targeted theranostics in oncology. Eur J Nucl Med Mol Imaging. 2022 Oct;49 (12) :4133-4144. |[2]Schwarzenböck SM, et al. [68Ga]pentixafor for CXCR4 imaging in a PC-3 prostate cancer xenograft model - comparison with [18F]FDG PET/CT, MRI and ex vivo receptor expression. Oncotarget. 2017 Sep 16;8 (56) :95606-95619.|[3]Chen Z, et al. Nuclear Medicine Application of Pentixafor/Pentixather Targeting CXCR4 for Imaging and Therapy in Related Disease. Mini Rev Med Chem. 2023;23 (7) :787-803.|[4]Poschenrieder A, et al. First 18F-Labeled Pentixafor-Based Imaging Agent for PET Imaging of CXCR4 Expression In Vivo. Tomography. 2016 Jun;2 (2) :85-93.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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