Agelenin

Agelenin is a polypeptide composed of 35 amino acids. Agelenin could be isolated from the Agelenidae spider Agelena opulenta. Agelenin has structural similarity to insect-specific calcium channel inhibitor[1].

Product Specifications

CAS Number

[142582-60-3]

UNSPSC

12352209

Target

Calcium Channel

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/agelenin.html

Solubility

10 mM in DMSO

Smiles

O=C(CN)NCC(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2[C@H](C(N[C@H](C(N[C@H]3CSSC[C@H](NC4=O)C(N[C@H](C(N)=O)CC(C)C)=O)=O)CCCNC(N)=N)=O)CCC2)=O)=O)CO)=O)CC(C)C)=O)C)=O)CC(N)=O)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]4CCCNC(N)=N)=O)CO)=O)CC(O)=O)=O)CC6=CNC7=CC=CC=C67)=O)[C@H](CC)C)=O)CO)=O)CC(C)C)=O)CCC(O)=O)=O)CCCCN)=O)=O)CC8=CC=CC=C8)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC9=CNC=N9)=O)CCC1)=O)CC(C)C)=O)CSSC[C@H](NC3=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5CCCCN)=O)CC(C)C)=O)=O)CO)=O)=O

Molecular Formula

C160H254N52O45S6

Molecular Weight

3815.75

References & Citations

[1]Yamaji N, et, al. Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors. FEBS Lett. 2007 Aug 7;581 (20) :3789-94.