PROTAC Bcl-xL degrader-2
Product Specifications
UNSPSC Description
PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM.
Target Antigen
Bcl-2 Family; PROTACs
Type
Reference compound
Related Pathways
Apoptosis;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-bcl-xl-degrader-2.html
Smiles
O=C(C1=C(CCCOC2=CC=C(C#CCOCCOCCOCCOCCOCCOCCC(N[C@H](C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)C=C2)SC(N6CC7=C(C=CC=C7C(NC8=NC9=CC=CC=C9S8)=O)CC6)=N1)O
Molecular Weight
1329.60
References & Citations
[1]Chun-Wa Chung, et al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139309/PROTAC-Bcl-xL-degrader-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139309/PROTAC-Bcl-xL-degrader-2-SDS-MedChemExpress.pdf
CAS Number
2920415-08-1
Available Sizes
Curated Selection
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