SB 204990
SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.
Product Specifications
CAS Number
154566-12-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
ATP Citrate Lyase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/SB_204990.html
Purity
99.75
Solubility
DMSO : ≥ 100 mg/mL|H2O : 25 mg/mL (ultrasonic)
Smiles
O=C(O)C[C@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O
Molecular Formula
C18H22Cl2O5
Molecular Weight
389.27
Precautions
H302, H315, H319
References & Citations
[1]Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293 (41) :16019-16027.|[2]Pearce NJ, et al. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem J. 1998 Aug 15;334 (Pt 1) :113-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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