SB 204990

SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY) enzyme.

Product Specifications

CAS Number

[154566-12-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

ATP Citrate Lyase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/SB_204990.html

Purity

99.75

Solubility

DMSO : ≥ 100 mg/mL|H2O : 25 mg/mL (ultrasonic)

Smiles

O=C(O)C[C@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Molecular Formula

C18H22Cl2O5

Molecular Weight

389.27

Precautions

H302, H315, H319

References & Citations

[1]Shares BH, et al. Active mitochondria support osteogenic differentiation by stimulating β-catenin acetylation. J Biol Chem. 2018 Oct 12;293 (41) :16019-16027.|[2]Pearce NJ, et al. The role of ATP citrate-lyase in the metabolic regulation of plasma lipids. Hypolipidaemic effects of SB-204990, a lactone prodrug of the potent ATP citrate-lyase inhibitor SB-201076. Biochem J. 1998 Aug 15;334 (Pt 1) :113-9.