A2B receptor antagonist 2

A2B receptor antagonist 2 (compound 18) is an adenosine receptor A2B antagonist, with Ki values of 2.30 μM, 6.8 μM and 3.44 μM for rA1, rA2A and hA2B, respectively[1].

Product Specifications

CAS Number

[784-90-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/a2b-receptor-antagonist-2.html

Purity

99.6

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

NC(NC1=NC(C)=C2C=C(C)C(C)=CC2=N1)=N

Molecular Formula

C12H15N5

Molecular Weight

229.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Thomas R Webb, et al. Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors. Bioorg Med Chem. 2003 Jan 2;11 (1) :77-85.