A2ti-1
A2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM[1]. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection[2].
Product Specifications
CAS Number
570390-00-0
UNSPSC
12352005
Target
Annexin A; HPV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Cytoskeleton
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/a2ti-1.html
Purity
99.78
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N)CSC1=NN=C(COC2=CC=CC=C2C)N1C3=CC=CC=C3CC
Molecular Formula
C20H22N4O2S
Molecular Weight
382.48
References & Citations
[1]Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7 (8) :1435-46.|[2]Andrew W Woodham, et al. Small Molecule Inhibitors of the Annexin A2 Heterotetramer Prevent Human Papillomavirus Type 16 Infection. J Antimicrob Chemother. 2015;70 (6) :1686-90.|[3]Weng M, et al. Pseudorabies Virus Regulates the Extracellular Translocation of Annexin A2 To Promote Its Proliferation. J Virol. 2023 Mar 30;97 (3) :e0154522.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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