MC-GGFG-Exatecan
MC-GGFG-Exatecan (MC-GGFG-DX8951) is a agent-linker conjugate for ADC. MC-GGFG-Exatecan is a DX8951 (a DNA topoisomerase I inhibitor) derivative with protease cleavable MC-GGFG linker. MC-GGFG-Exatecan shows antitumor activity and can be used to prepare DX8951 antibody conjugate (ADC) [1].
Product Specifications
CAS Number
[1600418-29-8]
Product Name Alternative
MC-GGFG-DX8951
UNSPSC
12352203
Hazard Statement
H301, H311, H331, H341
Target
Drug-Linker Conjugates for ADC; Topoisomerase
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc-ggfg-exatecan.html
Purity
99.71
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1OCC2=C(C=C(C3=NC4=CC(F)=C(C)C(CC[C@@H]5NC(CNC([C@@H](NC(CNC(CNC(CCCCCN6C(C=CC6=O)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=C4C5=C3C8)N8C2=O)[C@@]1(O)CC
Molecular Formula
C49H51FN8O11
Molecular Weight
946.97
Precautions
H301, H311, H331, H341
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Camptothecins
Available Sizes
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